Biomarkers for Circadian Timing in Healthy Adults (NCT03956745) | Clinical Trial Compass
TerminatedNot Applicable
Biomarkers for Circadian Timing in Healthy Adults
Stopped: Grant funding supporting the study ended.
United States15 participantsStarted 2021-06-01
Plain-language summary
Study investigators want to learn more about the underlying biological clock and to see if the timing of that clock can be estimated from a single blood sample.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Healthy adults with conventional and regular sleep-wake timing
* Non-smokers
* Able to spend 7 consecutive days/nights in the laboratory
* Willing to abstain from use of caffeine, nicotine, and alcohol during pre-study and study periods
Exclusion Criteria:
* History of neurological or psychiatric disorder
* History of sleep disorder or regular use of sleep-promoting medication
* Current prescription, herbal, or over-the-counter medication use
* Traveling across 2 or more time zones within the past 3 months
* Donating blood within the past 8 weeks
* Worked night or rotating shiftwork within the past 3 years
* Hearing impairment
* Drug or Alcohol dependency
* Pregnant, intending to become pregnant, or recently pregnant (last 6 months)
* Breastfeeding within the past 6 months
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Circadian Phase Timing by BodyTime Assay - Baseline Segment
Timeframe: Baseline Segment (Study day 3)
2
Circadian Phase Timing by BodyTime Assay - Constant Routine
Timeframe: During Constant Routine (Study days 4-5)
3
Circadian Phase Timing by BodyTime Assay - Inverted Day