TerminatedNot Applicable

Biomarkers for Circadian Timing in Healthy Adults

Stopped: Grant funding supporting the study ended.

United States15 participantsStarted 2021-06-01

Plain-language summary

Study investigators want to learn more about the underlying biological clock and to see if the timing of that clock can be estimated from a single blood sample.

Who can participate

Age range18 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy adults with conventional and regular sleep-wake timing * Non-smokers * Able to spend 7 consecutive days/nights in the laboratory * Willing to abstain from use of caffeine, nicotine, and alcohol during pre-study and study periods Exclusion Criteria: * History of neurological or psychiatric disorder * History of sleep disorder or regular use of sleep-promoting medication * Current prescription, herbal, or over-the-counter medication use * Traveling across 2 or more time zones within the past 3 months * Donating blood within the past 8 weeks * Worked night or rotating shiftwork within the past 3 years * Hearing impairment * Drug or Alcohol dependency * Pregnant, intending to become pregnant, or recently pregnant (last 6 months) * Breastfeeding within the past 6 months

What they're measuring

Circadian Phase Timing by BodyTime Assay - Baseline Segment

Timeframe: Baseline Segment (Study day 3)

Circadian Phase Timing by BodyTime Assay - Constant Routine

Timeframe: During Constant Routine (Study days 4-5)

Circadian Phase Timing by BodyTime Assay - Inverted Day

Timeframe: Inverted Day (Study days 6-7)

Trial details

NCT IDNCT03956745

SponsorBrigham and Women's Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-12-31

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