This multi-center retrospective cohort study presents a detailed assessment of augmented renal clearance (ARC) in a mixed population of adult critically ill patients. Epidemiology of ARC will be studied in detail in a very heterogeneous population. Risk factors for ARC will be identified and a predictive scoring system for ARC ready to use in clinical practice will be constructed and validated. Performance of estimators of kidney function will be measured and a cutoff for ARC will be determined for the best estimator. Finally clinical impact of ARC will be explored using vancomycine and aminoglycosides levels as surrogate marker.
Age range
18 Years
Sex
ALL
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ARC incidence per day
Timeframe: Retrospective analysis between January 2013 and December 2015
ARC incidence per admission
Timeframe: Retrospective analysis between January 2013 and December 2015
Duration and course of ARC episodes
Timeframe: Retrospective analysis between January 2013 and December 2015
ARC daily prevalence
Timeframe: Retrospective analysis between January 2013 and December 2015
Logistic regression with ARC as dependent variable
Timeframe: Retrospective analysis between January 2013 and December 2015
Predictive algorithm for ARC
Timeframe: Retrospective analysis between January 2013 and December 2015
Most precise formula using Bland-Altman agreement analysis
Timeframe: Retrospective analysis between January 2013 and December 2015
Performance of the best cutoff for ARC using ROC curve analysis
Timeframe: Retrospective analysis between January 2013 and December 2015
Exploration of clinical impact of ARC via surrogate markers
Timeframe: Retrospective analysis between January 2013 and December 2015