This multi-center retrospective cohort study presents a detailed assessment of augmented renal clearance (ARC) in a mixed population of adult critically ill patients. Epidemiology of ARC will be studied in detail in a very heterogeneous population. Risk factors for ARC will be identified and a predictive scoring system for ARC ready to use in clinical practice will be constructed and validated. Performance of estimators of kidney function will be measured and a cutoff for ARC will be determined for the best estimator. Finally clinical impact of ARC will be explored using vancomycine and aminoglycosides levels as surrogate marker.
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ARC incidence per day
Timeframe: Retrospective analysis between January 2013 and December 2015
ARC incidence per admission
Timeframe: Retrospective analysis between January 2013 and December 2015
Duration and course of ARC episodes
Timeframe: Retrospective analysis between January 2013 and December 2015
ARC daily prevalence
Timeframe: Retrospective analysis between January 2013 and December 2015
Logistic regression with ARC as dependent variable
Timeframe: Retrospective analysis between January 2013 and December 2015
Predictive algorithm for ARC
Timeframe: Retrospective analysis between January 2013 and December 2015
Most precise formula using Bland-Altman agreement analysis
Timeframe: Retrospective analysis between January 2013 and December 2015
Performance of the best cutoff for ARC using ROC curve analysis
Timeframe: Retrospective analysis between January 2013 and December 2015
Exploration of clinical impact of ARC via surrogate markers
Timeframe: Retrospective analysis between January 2013 and December 2015