WithdrawnNot Applicable

The Healing of Soft Tissue Augmentation by Acellular Dermal Matrix and Autogenous Subepithelial Connective Tissue Graft

Stopped: Withdrawn with IRB

0Started 2021-03

Plain-language summary

The study team proposes to prospectively compare the healing outcomes of autogenous soft tissue connective tissue graft (CTG) and Acellular dermis matrix (ADM) in a split-mouth design study for patients requiring modification of gingival soft tissue biotype. The researchers aim to investigate the earlier phase of graft healing after the grafting surgery by biopsy histology and by examining the alteration of gene profile during the healing of gingival tissue healing by molecular cell biological techniques.

Who can participate

Age range18 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * general healthy * periodontal healthy (no PD \>3mm, no BOP, no mobility at the test site and control site) * patients identified need gingival biotype modification (need for increased tissue thickness) during the periodontal exam or referred from orthodontics Exclusion Criteria: * current smoker or smoking history * taking Antibiotics or medicines within the last 3 months * past history of gingival soft tissue augmentation/modification surgery

What they're measuring

The histological analysis of the gingival biopsy tissue.

Timeframe: Month 3---after the gingival biopsy procedures

Trial details

NCT IDNCT03954028

SponsorUniversity of Florida

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-03

View on ClinicalTrials.gov More Gingival Recession, Generalized trials