RecruitingNot Applicable

Smoking Cessation Behavioral Treatment Study

United States200 participantsStarted 2019-12-19

Plain-language summary

The purpose of this study is to evaluate the effectiveness of two behavioral interventions on smoking behavior - Mindfulness-Oriented Recovery Enhancement (MORE) and Cognitive Behavioral Therapy (CBT). MORE is a behavioral therapy that integrates mindfulness training to modify reward processes. CBT is a therapy designed to help individuals understand how their thoughts and feelings influence their behaviors.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18 and up * English fluency as demonstrated in providing informed consent and the ability to independently follow directions in completing assigned assessments and tasks * Functional vision (with corrective lenses as needed) to complete assigned assessments and tasks * Current nicotine dependent smoker with a minimum smoking history of 2 years * Interest in quitting smoking Exclusion Criteria: * Use of psychotropic (e.g. antiepileptic) medications in the past month * Positive urine drug screen * Presence of an untreated medical illness * Current or past psychosis * History of major neurological illness or head injury resulting in loss of consciousness * And contraindication to MRI, including claustrophobia * Among females, positive urine pregnancy test * Inability or unwillingness of subject to give informed consent

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Cigarette Smoking

Timeframe: 7 weeks

Magnitude of change in fMRI brain response to images

Timeframe: 7 weeks

Magnitude of change in fMRI brain connectivity

Timeframe: 7 weeks

Trial details

NCT IDNCT03948893

SponsorUniversity of Missouri-Columbia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-31

Contact for this trial

Madhura Athreya, MS

5738822977 athreyam@health.missouri.edu

View on ClinicalTrials.gov More Tobacco Use Disorder trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.