CompletedPhase 4

Luteal Support in Frozen-Thawed Embryo Transfer Cycles

Turkey (Türkiye)151 participantsStarted 2021-06-30

Plain-language summary

This study evaluates the clinical efficacy of 3 different luteal phase support in patients undergoing frozen-thawed embryo transfer cycles. Endometrium preparation will be hormone replacement in all cycles. Starting from day 11, group 1 will receive 100 mg micronized progesterone parenteral daily injections, group 2 will receive 90 mg bioadhesive gel vaginal twice daily and group 3 will receive 40 mg oral dydrogesterone daily tablets.

Who can participate

Age range

20 Years – 40 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * woman aged 20-40 years * Having available blastocyst(s) cryopreserved by vitrification method. Exclusion Criteria: * requirement for fresh embryo(s); * presence of any clinically relevant systemic disease contraindicated for assisted reproduction or pregnancy * history of more than three failed cycles of IVF * history of recurrent abortions * allergy history for relevant drugs * body mass index of \<18 or \>38 kg/m2 at screening * current breastfeeding or pregnancy * refusal or inability to comply with the requirements of the protocol for any reason, including scheduled clinic visits and laboratory tests * trophectoderm or blastomere biopsy of the blastocyst(s) to be transferred

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

ongoing pregnancy rate

Timeframe: 12th week of pregnancy

Trial details

NCT IDNCT03948022

SponsorCentrum Clinic IVF Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-12-18

View on ClinicalTrials.gov More Implantation; Placenta trials