In summary, the investigators propose to study elite Croatian breath-hold and SCUBA divers. The investigators will quantify breath-hold hypoxia- and SCUBA diving-induced pulmonary hypertension and right heart function to investigate the relationships between PFO and IPAVA blood flow. The investigators will use a placebo-controlled intervention (sildenafil) to reduce pulmonary arterial pressure in these subjects to examine the impact of the change in pressure (or absence of change) on the relationships determined above.
Age range
18 Years – 65 Years
Sex
ALL
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Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Pulmonary Pressure
Timeframe: 1 hour post intervention
Concentration of Myoglobin
Timeframe: 1 hour post intervention
Concentration of MRP8/14
Timeframe: 1 hour post intervention
Concentration of NGAL
Timeframe: 1 hour post intervention
Concentration Of CRP
Timeframe: 1 hour post intervention
Concentration Of MMP-2
Timeframe: 1 hour post intervention
Concentration of OPN
Timeframe: 1 hour post intervention
Concentration Of SAA
Timeframe: 1 hour post intervention
Concentration of IGFBP-4
Timeframe: 1 hour post intervention
Concentration of ICAM-1
Timeframe: 1 hour post intervention
Concentration of VCAM-1
Timeframe: 1 hour post intervention
Concentration of MMP-9
Timeframe: 1 hour post intervention
Concentration of Cystatin C
Timeframe: 1 hour post intervention
Change in Q-IPAVA
Timeframe: 1 hour post intervention