The Effects of Replacing Red and Processed Meat With Quorn on Biomarkers of Gut Health (NCT03944421) | Clinical Trial Compass
CompletedNot Applicable
The Effects of Replacing Red and Processed Meat With Quorn on Biomarkers of Gut Health
United Kingdom20 participantsStarted 2019-07-03
Plain-language summary
This study will evaluate the effects of substituting red and processed meat in the diet with Quorn; a meat replacement product, on biomarkers of gut health. This will be a crossover design where participants will take part in 2 study periods where they will consume a diet containing red and processed meat during one of the study periods, whereas in the other study period, they will consume a diet containing Quorn.
Who can participate
Age range18 Years – 50 Years
SexMALE
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Inclusion Criteria:
* Male
* 18-50 years.
* Not been diagnosed with colorectal cancer, or adenomas.
* Habitual omnivorous dietary pattern.
* BMI ≥18-30 kg/m2.
* Blood HbA1c \<58mmol/mol (\<6.5%) (not diagnosed with diabetes)
* Fasting total cholesterol\<7.8 mmol/l
* Triglycerides \<2.3 mmol/l
* Normal liver function (assessed by measuring liver enzymes in the screening blood sample).
* Blood pressure lower than BP \<140/90 mmHg.
* Not suffering any cardiovascular diseases/ heart diseases e.g. stroke in the past 12 months.
* Do not suffer from chronic gastrointestinal problems (e.g. Inflammatory Bowel Disease, Irritable Bowel Syndrome, coeliac disease)
* Do not take supplements or medication that effects gastrointestinal health
* Not participated in a pre-/probiotic or laxative trial within the previous 3 months.
* Not been prescribed and/or taken antibiotics in the previous 6 months.
* No history of alcohol misuse based on self-reported alcohol intake and measurement of liver enzymes in the screening blood sample.
Exclusion Criteria:
* Been diagnosed with colorectal cancer and/or colorectal adenomas.
* Been diagnosed with gastrointestinal disorders (e.g. Inflammatory bowel disease, irritable bowel syndrome, coeliac disease)
* Adherence to a dietary pattern which excludes foods from an animal origin.
* Abnormal blood biochemistry based on standard clinical cut- offs, as well as blood markers not fitting the inclusion criteria set.
* Have history of food intolerances/allergi…
What they're measuring
1
Genotoxic potential of Faecal extracts from volunteers consuming intervention diets rich in red and processed meat versus diets containing Quorn
Timeframe: 2 weeks- Change from baseline following two week intervention with meat versus Quorn consumption