UnknownPhase 4

Lumbar Puncture in Emergency Under Nitrous OXide

France88 participantsStarted 2019-11-27

Plain-language summary

Lumbar puncture (LP) is a frequent exam that can cause pain and anxiety. In a scheduled setting, it has been shown that nitrous oxide use during the procedure was able to reduce both pain and anxiety. The goal of this trial is to confirm these results in a more heterogeneous group of patients having a LP, in an emergency setting.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult patients coming in emergency service who need a lumbar puncture in emergency for a diagnostic purpose * at least 18 * affiliated to the French state healthcare insurance system * able to give consent to participation Exclusion Criteria: * Previous use of nitrous oxide (medical or recreational) * Contra-indication to nitrous oxide use * Face mask phobia * Stage II obesity (BMI \> 35) * Hemodynamic instability and/or any case when coagulation results cannot be waited * Cognitive condition defined by a previous Mini Mental State Examination \< 24/30 * Confusion or any consciousness disorder that might interfere with judgment or consent * Patient unable to communicate verbally * Patient placed under a legal protection measure (tutorship, curatorship or a mandate) * Any medical condition that might contra-indicate medical research, in physician's opinion

What they're measuring

Maximal pain perceived during the lumbar puncture evaluated using a simple numeric 0-10 pain scale

Timeframe: 2-3 minutes after the end of gas inhalation

Trial details

NCT IDNCT03941990

SponsorUniversity Hospital, Clermont-Ferrand

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-04

Contact for this trial

Lise LACLAUTRE, Dr

(0)473754963 promo_interne_drci@chu-clermontferrand.fr

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