Albumin for Management of Hypervolemic Hyponatremia (AlbuCAT)

Exclusion criteria

• ✕. Patients with Acute kidney injury 1B or higher;
• ✕. Chronic kidney disease grade 3a or higher, defined as glomerular filtration rate \<60ml/min for three months and markers of kidney damage (one or more): Albuminuria (Albumin excretion rate \> 30 mg/24h; Albumin-to-creatinine ratio \> 30 mg/g), Urine sediment abnormalities, Electrolyte and other abnormalities due to tubular disorders, Electrolyte and other abnormalities due to tubular disorders, Abnormalities detected by histology or Structural abnormalities detected by imaging.
• ✕. Previous kidney or liver transplant;
• ✕. Active infection apart from spontaneous bacterial peritonytis based on positive culture (blood, urine, sputum or other samples) or by the following criteria:
• ✕. Urinary infections: signs of systemic inflammation and more than 10 leukocytes per high-power field in urine;
• ✕. Pneumonia: compatible symptoms (cough, purulent sputum, chest pain, shortness of breath) and presence of new infiltrates on chest x-ray;
• ✕. Skin/soft tissue infection: physical exam findings of swelling, erythema, heat and tenderness in the skin;
• ✕. Acute cholangitis: signs of systemic inflammation1, compatible symptoms (right upper quadrant pain and jaundice) and radiological data of biliary obstruction, analytical data of cholestasis;