CompletedNot Applicable

Traumatic Brain Injury Associated Radiological DVT Incidence and Significance Study

United Kingdom90 participantsStarted 2019-09-28

Plain-language summary

Whilst deep vein thrombosis (DVT) is common following traumatic brain injury (TBI), optimal timing and safety of pharmacological prophylaxis is uncertain. Paradoxically the harm associated with the occurrence of is also unclear. This study is an observational pilot that aims to define the incidence of proximal DVT in patients with moderate to severe TBI. It seeks prospectively to determine if there is an association between DVT and outcome. It also seeks to explore possible associations between the occurrence of DVT and the incidence of lung injury and/or ventilator associated pneumonia.

Who can participate

Age range16 Years

SexALL

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Inclusion criteria

✓. Age ≥ 16 years
✓. Admission to critical care
✓. moderate/severe, non-penetrating traumatic brain injury
✓. Abnormal brain CT Scan
✓. Post resuscitation Glasgow coma score (GCS) ≤12, or GCS motor component ≤5
✓. Able to complete consent and first USS within 72 hours of injury

Exclusion criteria

✕. Normal brain CT scan
✕. Unlikely to survive for the next 24 hours in the opinion of the ICU Consultant or Consultant Neurosurgeon treating the patient
✕. Contra indication to normal prophylactic measures, including heparin, were indicated
✕. Known blood clotting disorder or thrombophilia
✕. Significant pelvic or lower limb trauma

What they're measuring

Incidence of proximal DVT by compression ultra sound

Timeframe: within 72 hours of injury until day 10 post injury.

Trial details

NCT IDNCT03937947

SponsorNHS Lothian

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2023-09-24

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