CompletedNot Applicable

The Effect of Iloprost on Oxygenation During One-lung Ventilation for Lung Surgery

South Korea72 participantsStarted 2018-01-04

Plain-language summary

During one-lung ventilation in patients undergoing thoracic surgery, the persistent flow in the non-ventilated lung increases intrapulmonary shunt and decreases systemic arterial oxygenation. This prospective, randomized, double blind study was conducted to evaluate the effects of inhaled iloprost during one-lung ventilation on arterial oxygenation and shunt fraction during thoracic surgery.

Who can participate

Age range20 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * elective video-assisted thoracoscopic surgery (VATS) lobectomy * 20 \< age \< 75 * American Society of Anesthesiologists (ASA) classification I\~III Exclusion Criteria: * ASA classification IV * New York Heart Association (NYHA) class III\~IV * Severe obstructive lung disease / restrictive lung disease * Pulmonary hypertension * End-stage organ disease (i.e. hepatic failure, renal failure) * Arrhythmia * Previous history of thoracic surgery

What they're measuring

PaO2(partial pressure of arterial oxygen)

Timeframe: 30 min after treatment

Pulmonary shunt fraction

Timeframe: 30 min after treatment

Trial details

NCT IDNCT03936140

SponsorSeoul St. Mary's Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-10-24

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