CompletedNot Applicable

Circulating miRNA in Primary Hyperparathyroidism

United States96 participantsStarted 2018-09-07

Plain-language summary

The goal of this study is to: 1. Analyze the expression levels of circulating (serum) miRNAs in primary hyperparathyroidism patients with and without osteoporosis, and patients with osteoporosis undergoing thyroidectomy, and to correlate with clinical markers of bone remodeling including biochemical and radiologic studies. 2. To evaluate serum miRNA levels after treatment with parathyroidectomy.

Who can participate

Age range

50 Years – 100 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * post menopausal * has had DXA scan * has 24 hr Urine Calcium * Elevated serum calcium * Vitamin D above 20 ng/ml * capable of giving informed consent * female * indication for biochemical primary hyperparathyroidism or an indication for partial or total thyroidectomy Exclusion Criteria: * history of ESRD on dialysis or renal osteodystrophy * prior parathyroidectomy * hyper or hypothyroid by TSH * currently taking steroids or has been on steroids for more than 7 days in the last two years * estrogen therapy within the last two years * bisphosphonate therapy within the last two years * diagnosis of Cushing's disease or Cushing's syndrome * taking biotin within 24 hours of blood draw

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

circulating microRNAs in primary hyperparathyroidism patients

Timeframe: 2019-2021

serum miRNA after parathyroidectomy

Timeframe: 2019-2021

Trial details

NCT IDNCT03931109

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-07-01

View on ClinicalTrials.gov More Primary Hyperparathyroidism trials