CompletedNot Applicable

Predicting Treatment Response to Exposure Therapy Using Carbon Dioxide

United States70 participantsStarted 2018-06-07

Plain-language summary

Anxiety disorders affect over a quarter of the population, yet very little is known about the variables that predict treatment outcome. The planned study explores whether a patient's response to a physiological test involving inhalation of carbon dioxide predicts their response to exposure therapy.

Who can participate

Age range18 Years – 55 Years

SexALL

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Inclusion criteria

✓. DSM-V diagnosis of an Anxiety disorder (Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia)
✓. Anxiety Sensitivity Index (ASI-3) total score \> 29
✓. Overall Anxiety Severity and Impairment Scale (OASIS) score \> 8
✓. Between 18-55 years of age
✓. Subject must be "treatment-seeking" and willing to enroll in the 10-week group-based Exposure Therapy

Exclusion criteria

✕. Comorbid Bipolar Disorder, Schizophrenia, Anorexia or Bulimia Nervosa, or Obsessive-Compulsive Disorder
✕. Current Substance Use Disorder \> moderate (within the past 6 months)
✕. Currently taking a psychotropic medication
✕. Currently receiving psychotherapy/counseling for anxiety
✕. Currently being treated as an inpatient
✕. Active suicidal ideation with intent or plan
✕. History of neurological, cardiovascular or respiratory problems (e.g., asthma, severe brain injury)

What they're measuring

Between-session habituation of self-reported anxiety

Timeframe: Across two days of CO2 testing within a 72-hour window

Trial details

NCT IDNCT03925987

SponsorLaureate Institute for Brain Research, Inc.

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-01-31

View on ClinicalTrials.gov More Generalized Anxiety Disorder trials