Predicting Treatment Response to Exposure Therapy Using Carbon Dioxide (NCT03925987) | Clinical Trial Compass
CompletedNot Applicable
Predicting Treatment Response to Exposure Therapy Using Carbon Dioxide
United States70 participantsStarted 2018-06-07
Plain-language summary
Anxiety disorders affect over a quarter of the population, yet very little is known about the variables that predict treatment outcome. The planned study explores whether a patient's response to a physiological test involving inhalation of carbon dioxide predicts their response to exposure therapy.
Who can participate
Age range
18 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. DSM-V diagnosis of an Anxiety disorder (Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia)
. Anxiety Sensitivity Index (ASI-3) total score \> 29
. Subject must be "treatment-seeking" and willing to enroll in the 10-week group-based Exposure Therapy
Exclusion criteria
. Comorbid Bipolar Disorder, Schizophrenia, Anorexia or Bulimia Nervosa, or Obsessive-Compulsive Disorder
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial used carbon dioxide to predict how well someone might respond to exposure therapy for anxiety disorders like generalized anxiety, social anxiety, panic disorder, or agoraphobia — could the findings from this study help predict whether exposure therapy is likely to work for my specific situation?
2Since this trial measured 'between-session habituation,' meaning how much anxiety naturally decreases between therapy sessions, what does that kind of measurement tell us about whether I'm a good candidate for exposure therapy versus another treatment approach?
3This study is now completed — are the results published or available, and do they change your recommendation for how I should approach treatment for my anxiety disorder?
4If exposure therapy is what this research was designed to evaluate, is that something you'd consider the right first step for me, or would you recommend trying medication or another therapy before going that route?
5Could participating in or benefiting from research like this one change the order in which we try different treatments for my anxiety, and is there a similar study still enrolling that might be worth looking into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Between-session habituation of self-reported anxiety
Timeframe: Across two days of CO2 testing within a 72-hour window
Trial details
NCT IDNCT03925987
SponsorLaureate Institute for Brain Research, Inc.