TerminatedNot Applicable

Recovery of Ventilation After General Anesthesia in Morbidly Obese Patients

Stopped: Lack of resources and COVID-related closure in 2020.

United States8 participantsStarted 2019-04-10

Plain-language summary

This is an observational study of morbidly obese patients recovering from general anesthesia after weight-loss surgery. The investigators aim to assess ventilatory function and how this is influenced by the diagnosis of obstructive sleep apnea (OSA), baseline ventilatory status, as well as pharyngeal collapsibility of patients who are recovering from anesthesia and treated for pain with opioids. The investigators hypothesize that patients with OSA, chronic (baseline) hypoventilation and increased pharyngeal collapsibility, will be more vulnerable to opioid-induced ventilatory depression.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Body mass index (BMI) equal or greater than 35 kg/m2. * American Society of Anesthesiologists (ASA) physical status I - III patients. * Scheduled to undergo laparoscopic roux-en-Y gastric bypass or gastric sleeve placement surgery for weight loss. Exclusion Criteria: * Chronic obstructive pulmonary disorder (COPD). * Treatment with continuous positive airway pressure (CPAP) in the past three months. * Severe neurological, cardiopulmonary, psychiatric, or untreated thyroid disorder. * Chronic pain condition that was being treated with opioids. * Patients with a hematocrit lower than 35%.

What they're measuring

Probability for TcPCO2 / PaCO2 to exceed a pre-specified threshold during recovery from anesthesia.

Timeframe: PACU period (approximate duration of about 1.5h).

Trial details

NCT IDNCT03925610

SponsorStanford University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-03-30