CompletedNot Applicable

Neuropeptides and Venous Pelvic Pain

Russia120 participantsStarted 2019-04-01

Plain-language summary

Mechanisms of the development of pain in chronic venous diseases (CVD), including pelvic congestion syndrome (PCS), are studied incompletely. The existing hypotheses of the occurrence of venous pelvic pain (VVP) do not allow to answer the question why some patients have no pain syndrome while others have very pronounced pain despite the same morphofunctional changes in the pelvic veins? The investigators are planning to carry out a study aimed at studying the content of calcitonin gene-related peptide (CGRP) and substance P (SP) in the serum of patients with pelvic veins and pelvic pain, and to study the relationship between the values of CGRP and SP in these patients.

Who can participate

Age range18 Years – 45 Years

SexFEMALE

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Inclusion Criteria: * The reproductive age of the woman * Blood reflux in the parametric, uterine, gonadal veins * The absence of any concomitant pathology, accompanied by chronic pelvic pain Exclusion Criteria: * The absence of blood reflux in in the parametric, uterine, gonadal veins * The presence of diseases, the clinical course of which suggests the presence of chronic pelvic pain and other varieties of chronic pain, including migraine * Pregnancy

What they're measuring

The severity of venous pelvic pain

Timeframe: 5 min

The level of calcitonin-gene-related peptide

Timeframe: 22 hours

The level of substance P

Timeframe: 22 hours

Trial details

NCT IDNCT03921788

SponsorPirogov Russian National Research Medical University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-12-12

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