Isometric Exercise in NTG

1. Study population: patients with normal tension glaucoma * Caucasian men and women aged over 50 years * Subject is generally healthy with no current significant or a history of a significant neurological, cardiovascular, pulmonary (including asthma), hepatic, metabolic, rheumatic, autoimmune, hematological or renal disorder, as determined by the investigator's clinical judgment through collection of medical history and performance of a physical examination. A significant disorder is defined as a disease or medical condition associated with impaired health status, requiring regular or current medical treatment and/or follow up. For the purposes of this study, an investigator may classify a medical condition as a nonsignificant disorder despite the fact that the subject receives treatment. Subjects having controlled Stage 1 hypertension (blood pressure of 140-159 mmHg systolic and/or 90-99 mmHg diastolic) are eligible for participation in this study * Normal open angle in a gonioscopic examination * Presence of glaucomatous optic disc changes in biomicroscopy and * Visual field defects in at least two visual field examinations (Reliability criteria: fixation errors \< 20%, false positives \< 15%, and false negatives \< 33%) Or * Abnormal circumpapillary retinal nerve fiber layer thinning (RNFL evaluated by OCT) 2. Control group * Men and women aged over 18 years * Subject is generally healthy with no current significant or a history of a significant …