Neoadjuvant Cemiplimab for the Treatment of Resectable NSCLC, HCC, and HNSCC in Adult Patients

Key Inclusion Criteria: * Patient must have a known diagnosis of NSCLC, HCC, or HNSCC as defined in the protocol * Patient must be willing and able to provide blood samples at the indicated time points * Patient must be willing and able to have excisional or core needle biopsies of tumor prior to initiation of cemiplimab as defined in the protocol * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 * Patient is determined to be a surgical candidate for resection of their tumor * Adequate organ and bone marrow function as defined in the protocol Key Exclusion Criteria: * Patients who have had any systemic anti-cancer therapy or radiotherapy within 6 months prior to entering the study for their current tumor or a different primary tumor * Patients whose tumor burden, or pace of tumor growth, in the opinion of the Investigator will not permit delaying surgery * Patients who have participated in a study of an investigational agent or an investigational device within 4 weeks of study therapy or 5 half-lives (whichever is longer) * Patients who have had major surgery within 14 days prior to initiation of neoadjuvant Therapy * Patients with metastatic disease for whom the intent of surgery would not be curative * Uncontrolled, intercurrent illness as defined in the protocol and as determined by the Investigator * Is receiving systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of study treatment * Has …