UnknownNot Applicable

CLBR Per Initial Cycle With Different Starting Dose in Aged Patients With Poor Ovarian Reservation: 300IU Versus 150IU

China260 participantsStarted 2019-04-23

Plain-language summary

Among aged patients with poor ovarian reservation(defined as age 35 to 42 years; antral follicle count（AFC）≤ 5 or anti-mullerian hormone（AMH）≤ 1.2 ng/ml), cumulative live birth rate(CLBR) and time to live birth(TTLB) of the first stimulation cycle were compared between a starting dose of 300IU or 150IU rFSH in controlled ovarian stimulation with gonadotropin-releasing hormone（GnRH）antagonist protocol. This study is a prospective randomized controlled trial.

Who can participate

Age range35 Years – 42 Years

SexFEMALE

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Inclusion criteria

✓. Age Limits≥35 and≤42；
✓. AFC≤5 or AMH≤1.2ng/ml；
✓. BMI≤30kg/m2；
✓. The first IVF/intracytoplasmic sperm injection （ICSI） cycle；

Exclusion criteria

✕. Any other underlying disease or condition considered IVF is contraindicated.
✕. Ovarian hyperstimulation syndrome（PCOS）, moderate or severe intrauterine adhesion，untreated hydrosalpinx, adenomyosis， any myoma in cases that endometrium was affected, intramural larger than 4cm.
✕. Autoimmune antibody positive, untreated.
✕. History of recurrent miscarriages.
✕. Patients seeking for Preimplantation Genetic Testing(PGT) treatment.
✕. Simultaneous participation in another clinical study.
✕. According to the judgment of the investigator, any reason or condition that precludes subject for participating in the study.

What they're measuring

Cumulative live birth rate

Timeframe: 22 months

Trial details

NCT IDNCT03914651

SponsorReproductive & Genetic Hospital of CITIC-Xiangya

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-12-30

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