Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE)

Inclusion Criteria: * child will be 8 - 36 months old when study treatment will be delivered * child has a diagnosis of Perinatal Arterial Stroke (PAS) * parent permission to provide the child's clinical MRI to the study * child has hemiparesis * parent(s) willing to participate in the home therapy component * one parent English language proficient and will take the lead in interacting with study staff and completing self-administered forms and interviews in English Exclusion Criteria: * child has medical or sensory condition(s) that prevent(s) full therapy participation (e.g., frequent uncontrolled seizures, fragile health) * child previously received Constraint-Induced Movement Therapy (CIMT) or modified CIMT with a dose of at least 2 hrs/day for ≥10 days * child received botulinum toxin in past 3 months * child is a ward of the state or other agency