Treatment of Coronary De-novo Stenosis by a Sirolimus Coated Balloon or a Paclitaxel Coated Balloon Catheter

Inclusion Criteria: * Clinical evidence of stable or unstable angina or a positive functional study * Patients with significant coronary de-novo stenosis (≥ 70% diameter stenosis or intermediate ≥ 50% to \<70% diameter stenosis with positive functional test or symptom of ischemia) * Successful lesion preparation (no flow-limiting dissection or a residual stenosis \> 30%) Exclusion Criteria: * Acute myocardial infarction within the past 72 hours (STEMI or NSTEMI) * Intolerance and / or allergy to Sirolimus * Intolerance or allergy to Paclitaxel and/or the delivery matrix (main ingredient: iopromide) * Patients with an ejection fraction of \< 30 % * Reference vessel diameter (RVD) \< 2.5 mm * Contraindication for whichever necessary accompanying medication