Multi-centre Acute Severe Ulcerative Colitis Prospective Cohort Study (Elevate ASUC) (NCT03907631) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Multi-centre Acute Severe Ulcerative Colitis Prospective Cohort Study (Elevate ASUC)
United Kingdom189 participantsStarted 2019-10-18
Plain-language summary
Up to one third of patients with Ulcerative Colitis (UC) will require hospitalisation for severe disease (ASUC - Acute Severe Ulcerative Colitis), often within the first 12 months of diagnosis. 30-40% of people admitted to hospital with ASUC will require colectomy during the emergency admission. Investigators will develop a multi-centre prospective inception cohort of patients with ASUC with homogeneously collected detailed longitudinal clinical, endoscopic and laboratory data.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* age 18 - 80 years.
* Confirmed acute severe ulcerative colitis based on modified Truelove and Witts criteria requiring hospital admission.
* Need for at least 2 days of intravenous steroids
* Able to sign consent
Exclusion Criteria:
* Crohn's disease
* Admission for elective colectomy
* Infective colitis confirmed on stool culture, assays for C. difficile or cytomegalovirus
* Pregnancy
* Inability to sign consent
* Prior colitis related surgery - pouch, stoma
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
In Hospital Outcomes
Timeframe: 30 days
2
Colectomy rates
Timeframe: 30 days
Trial details
NCT IDNCT03907631
SponsorHull University Teaching Hospitals NHS Trust