Effect of Nutrient Delivery Pattern on Biological Rhythms in Human Skeletal Muscle (NCT03906409) | Clinical Trial Compass
CompletedNot Applicable
Effect of Nutrient Delivery Pattern on Biological Rhythms in Human Skeletal Muscle
United Kingdom18 participantsStarted 2019-02-28
Plain-language summary
Recent work has established biological rhythms in human skeletal muscle. It remains unknown how the timing and pattern of meals influences these rhythms. Therefore, this study sets out to establish how frequent (CONSTANT) vs infrequent (BOLUS) feeding patterns influence established biological rhythms in skeletal muscle.
Who can participate
Age range18 Years – 45 Years
SexALL
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Inclusion Criteria:
* Body mass index \>19 but \<30 kg/m2
* Be able and willing to give informed oral and written consent, complete and meet the defined criteria of pre-study questionnaires and screens,
* Have a regular sleep cycle with a sleep duration between 6 and 8 hours, do not exhibit extreme morning or evening preference (Horne and Ostberg, 1976)
* Agree to keep a constant sleep/wake cycle with a self-selected 8 hour sleep duration (from which it cannot be deviated by more than 30 minutes) for one week prior to the lab study,
* Obtain 15 minutes of sunlight within 1.5 hours of waking up and agree to nap only within a 4 h designated nap window for one week prior to the lab study,
* Allow confirmation of compliance to these instructions by wearing ActiHeart monitors continuously and complete daily sleep and event diaries for one week before the study session,
* Agree to refrain from alcohol, caffeine, heavy exercise and certain food components TWO days before the study session,
* Agree to weigh and record daily meals (based on individual energy requirements) for TWO days prior to the study,
* Agree to refrain from prescribed and 'over the counter' medication and food/vitamin supplements for a wash-out period three weeks before and during the study.
Exclusion Criteria:
* Are taking regular medication (also non-prescribed) or food supplements (e.g vitamins, minerals, fish oil, antioxidant tablets) from which it is not possible to refrain, known to influence: Sleep/alert…
What they're measuring
1
Autophagy
Timeframe: 4 hours
2
Transcriptomic, rhythms in human skeletal muscle
Timeframe: Over a 24-hour period at a 4 hour resolution