CompletedPhase 1

Pleurodesis Using Hypertonic Glucose to Treat Post-operative Air Leaks

Canada12 participantsStarted 2019-09-17

Plain-language summary

The investigators will define the most appropriate safe dose of D50 to heal air leaks in patients that have undergone lung resection surgery

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. 18 years old or older
✓. Lung resection is a wedge, segmentectomy, lobectomy or bilobectomy
✓. Procedure performed by video-assisted thoracic surgery (VATS) or by Thoracotomy
✓. Presence of an air leak on the digital draining system on postoperative day 2

✕. Large air leak arbitrarily defined as more than 1000 mL/min
✕. Allergy to local anesthetics
✕. Hemodynamic instability
✕. Untreated coronary artery disease
✕. Need for respiratory support
✕. Any other early post-operative complication
✕. Immunity disorder
✕. Large pleural fluid output empirically defined as more than 500 mL in the last 12 hours

Occurrence of treatment related adverse events

Timeframe: 1 year

NCT IDNCT03905408

SponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-02-01