Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects (NCT03897855) | Clinical Trial Compass
CompletedNot Applicable
Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects
France20 participantsStarted 2019-04-01
Plain-language summary
In the elderly, we can see a post-traumatic syndrome associated with an event that occurred before old age that had not previously manifested or not fully manifested.
This little-known pathology and notable psychiatric co-morbidities (depression, anxiety) can take in elderly subjects different masks that interfere with diagnosis and treatment.
The data in the literature suggest that this Post-Traumatic Stress Disorder with Delayed Expression (TSPT-R) may be related to a deficiency of the executive functions of inhibition, and more particularly a deficit of mental memory inhibition and therefore the removal of unwanted memories.
Who can participate
Age range
65 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
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Regarding the constitution of the group patient (TSPT-R):
* Subjects 65 years of age or older
* Clinical diagnosis of delayed-onset PTSD according to DSM-5 criteria after 65 years
* The traumatic event must have taken place at the latest before 65 years
* Affiliated person or beneficiary of a social security scheme.
* Written consent before any examination required by research)
Regarding the constitution of the control group:
* Subjects 65 years of age or older
* No diagnosis of PTSD (delayed or not) or history of PTSD (delayed or not)
* Affiliated person or beneficiary of a social security scheme.
* Written consent before any examination required by the research).
Exclusion Criteria:
* For both groups:
* Acute or chronic cognitive impairment known
* GRECO MMSE pathological score less than or equal to the pathological threshold weighted according to level of education and age, namely:
* 22 if no diploma
* 23 if certificate of study
* 25 if patent
* 26 if bin or more
* Remove one point at each threshold if age\> 80 years
* Sensory or motor disorder preventing the passing of different tests
* Psychotic disorder
* Mood disorder in decompensation (for depression, HAD-D score equal to or greater than 11)
* Disorder of the use of a moderate or severe substance (except tobacco).
* Patients under guardianship or curatorship.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Inhibition score measured by the Think / No-Think Test