Beta-Lactams Dosing In Pneumonia in ICU in Patients Treated by Continuous Renal Replacement Therapy: the BLIPIC Study

Inclusion Criteria: * Aged ≥ 18 years * Receiving intraveinous beta-lactam : amoxicillin, amoxicillin-clavulanic acid, piperacillin-tazobactam, cefotaxime, ceftazidime, cefepime, meropenem, imipenem * With AKI defined as any of the following, and treated with Multifiltrate Ci-Ca CVVHD 1000® kit with a dialysis dose of 25 ml/kg/h : * Increase in creatininemia ≥ 0.3 mg/dl (≥ 26.5 µmol/l) within 48 hours * Increase in creatininemia ≥ 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days * Urine volume \< 0.5 ml/kg/h for 6 hours * Hospitalized in ICU * Presence of a catheter to facilitate sample collection * With pneumonia defined as any of the following : * Chest X-ray pneumonia : opacities, new or progressive infiltrates * AND at least one of the following : hyperthermia \> 38°C or hypothermia \< 36°C with no other explanation ; leukopenia \< 4 G/L ou leukocytosis \> 12G/L * AND at least one of the following : new onset purulent sputum or change in sputum character, new onset or worsening cough or dyspnea or tachypnea, rales or bronchial breathing, lower oxygen saturation/hypoxemia or increase of oxygen needs or respiratory assistance * Treated within 24 hours by citrate hemodialysis AND beta-lactam respecting dose and administration conditions of the study : * Amoxicillin : loading dose followed immediately by 2g by extended infusion for 4 hours every 8 hours * Amoxicillin-clavulanic acid : 2g every 8 hours by intermittent …