Transcriptome Assessment After Cardiac Arrest (NCT03895736) | Clinical Trial Compass
CompletedNot Applicable
Transcriptome Assessment After Cardiac Arrest
France60 participantsStarted 2020-02-24
Plain-language summary
The purpose of this study is to determine whether the blood transcriptome of patients resuscitated after out-of-hospital could be an early predictor of the neurological outcome.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age between 18 and 80 years
* Delay between patients collapse and resumption of spontaneous circulation (ROSC) \< 60 minutes
* Comatose patients ROSC with Glasgow score \< 7
* Patient already registered in the social security system
* Consent of a family member, if able to understand in the emergency context, or attestation of emergency situation with a follow-up information notice
Exclusion Criteria:
* Cardiac arrest supposed to be provoked by trauma or sepsis
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study already completed — does that mean results are available, and if so, what did the transcriptome data from blood samples taken at hospital admission reveal about predicting outcomes after cardiac arrest?
2The trial tracked a neurological outcome score called the Pittsburgh Cerebral Performance Category at 60 days — can you help me understand what that score measures and whether findings from this study could affect how my recovery or brain function would be monitored after a cardiac arrest?
3Since this was a study measuring gene expression in the blood right after resuscitation, does it represent any kind of treatment, or is it purely observational — and how might research like this eventually change the care someone in my situation receives?
4The trial focused on people who survived out-of-hospital cardiac arrest after successful resuscitation — given what this study found, are there any emerging approaches to early assessment or care after cardiac arrest that my care team might consider based on this type of research?
5Because this trial is completed rather than active, would my doctor be able to access its findings or connect me with researchers involved, so we can better understand whether its results are relevant to my specific situation?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Early Transcriptome at hospital admission
Timeframe: Day 0
2
Pittsburgh Cerebral Performance Category at Day 60