CompletedPhase 4

Papaverine vs Heparin for Peripheral Arterial Catheter Patency in Pediatric Patients

United States100 participantsStarted 2019-04-01

Plain-language summary

The purpose of this study is to compare intraoperative papaverine plus heparin to heparin alone for prevention of arterial spasm and maintenance of patency of peripheral arterial catheters during surgery in pediatric patients. The hypothesis is that periodic, intraoperative small-volume boluses of diluted papaverine plus heparin in peripheral arterial catheters of pediatric patients will prevent arterial spasm and help maintain patency of arterial catheters during general anesthesia.

Who can participate

Age range17 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: \- All patients age 0-17 years who would require elective placements of arterial catheters based on patients clinical complexity (ex. congenital heart disease) or based on the type of surgery (ex. open heart surgery). Exclusion Criteria: * Patients with a history of significant liver dysfunction. * Patients undergoing liver transplants. * Patients with Grade 2 or more of intraventricular hemorrhage. * All preterm patients with a gestational age less than 37 weeks at the time of surgery.

What they're measuring

Number of Participants With Optimal Arterial Waveform

Timeframe: 5 minutes after first dose

Trial details

NCT IDNCT03894904

SponsorThe University of Texas Health Science Center, Houston

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-10-10

Results submitted2021-09-29

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