Protocol of Diuretics Use in Congestive Therapy in Heart Failure (NCT03892148) | Clinical Trial Compass
CompletedPhase 4
Protocol of Diuretics Use in Congestive Therapy in Heart Failure
France299 participantsStarted 2019-05-17
Plain-language summary
The main objective of the study is to determine if a diuretic adaptation protocol in the decompensation of chronic heart failure is more effective but also safer than the current non-protocolized practice.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients hospitalized for chronic decompensated congestive heart failure without acute pulmonary edema and acute cardiac decompensation against a background of hypertensive crisis
* covered under a social security program
* with legal capacity to give voluntary informed consent to participate in the study
Exclusion Criteria:
* First episode of decompensated congestive heart failure
* Protocolized shock or hypotension (\<90 mmHg blood pressure) managed or requiring nitrovasodilators or non-invasive ventilation
* One of the following cardiovascular pathologies: acute myocardial infarction / cardiac tamponade / aortic dissection / acute pulmonary embolism / heart transplant / ventricular assist device / acute pulmonary edema / hypertensive crisis
* More than 12h of intravenous diuretics administered prior to inclusion
* Generalized edema caused by cirrhosis or nephrotic syndrome
* Requiring pleural or peritoneal tap for therapeutic purposes
* Patient allergic or intolerant to furosemide and on long-term bumetanide use
* Patient in dialysis or end-stage chronic kidney disease (CKD-EPI-calculated GFR \<15 mL/min/1.73m²) or acute kidney injury of known non-cardiac cause
* Severe hypokalemia (\< 3 mmol/L) on admission
* Patient who is pregnant, breastfeeding, or of childbearing age not on effective contraception
* Adult patient safeguarded under court protection measures (guardianship, wardship, or judicial protection)