Active — Not RecruitingNot Applicable

PRISM Intervention Study

United States140 participantsStarted 2021-03-01

Plain-language summary

This research study, Personalized, Responsive Intervention Sequences for Minimally Verbal Children with Autism (PRISM), is designed to maximize language outcomes for limited-language preschoolers, thereby lowering the risk of being classified as "minimally verbal" at age 6, by empirically developing a two-stage, 20-week adaptive intervention approach in a real world community settings. If found efficacious, the adaptive intervention design will capitalize on the heterogeneity and evolving status of children with ASD by providing the best intervention (DTT, JASPER and CET) for children who need it (leading to individualized sequences of intervention), only when it is needed (potentially reducing burden on children).

Who can participate

Age range36 Months – 59 Months

SexALL

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Inclusion Criteria: * children meeting ADOS-2 criteria for ASD, * age 36-59 months * who have had \> 3 months early intervention/preschool (to ensure that children already have been exposed to some community interventions) and * use \< 20 functional words (i.e., non-echoed, non-scripted). Additional inclusion criteria are: * stable medication over the past 6 months, and * nonverbal mental age of \>12 months on the Mullen Scales of Early Learning (visual reception and fine motor subscales). Exclusion Criteria: * We will exclude children who have sensory and motor impairments (e.g., visual impairment, deaf or hard of hearing) and with known genetic syndromes (e.g., Down Syndrome). * We will not exclude on the basis of AAC exposure, but expect few will be exposed at these ages.

What they're measuring

Change of spontaneous utterances (SCU) from the Language Sample throughout the study.

Timeframe: baseline (entry), 10 weeks after entry, 20 weeks after entry, 30 weeks after entry, and when child turns 6

Trial details

NCT IDNCT03883139

SponsorUniversity of California, Los Angeles

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-30