Cardiopulmonary bypass (CPB) is a unique clinical scenario that results in widespread activation of the hemostatic system. Conventional CPB interferes with normal hemostasis by diluting hemostatic cells and proteins, through reinfusion of shed blood, and through activation on the bypass circuit surface of multiple systems including platelets, the kallikrein-kinin system, and fibrinolysis . Besides, deleterious effects of cardiopulmonary bypass (CPB) are partly sequelae of blood-foreign surface reactions. The arterial filter is the part of the CPB circuit where blood cells are exposed to high mechanical stress and where cellular aggregates may fasten in large quantitiesiec.
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Types and characteristics of materials entrapped in the arterial line filter of cardiopulmonary bypass
Timeframe: At the beginning and end of cardiopulmonary bypass
Platelet and leukocyte gene expression analysis of arterial line filters of cardiopulmonary bypass
Timeframe: At the beginning and end of cardiopulmonary bypass