An Ascending Dose Comparison of MVT-100 to Definity in Healthy Volunteers

Inclusion Criteria: * Adult subjects 19 years of age or older, male or female * Female subjects must no longer have child-bearing potential (\>1-year post menopause or surgically sterilized), or must * have a negative urine pregnancy test, and * be using and continue to use for 30 days after the study a medically effective method of contraception * Adequate hematologic, renal and hepatic function, as defined by: * Absolute neutrophil count (ANC) ≥ 1.5 x 109/L * Platelet count ≥ 100 x 109/L * Hemoglobin ≥ 90 g/L * Plasma creatinine\< 1.5 x ULN * Total bilirubin within normal limits (\< 2.5 x ULN if Gilbert's syndrome) * Aspartate transaminase (AST) and Alanine transaminase (ALT) \< 2.5 x ULN * Subject must be willing and able to understand the study and provide written Informed Consent to participate in the study Exclusion Criteria: * Myocardial infarction within six months prior to enrollment * Unstable angina, NYHA Class II or greater congestive heart failure * EKG evidence of uncontrolled arrhythmia or history of clinically significant arrhythmia within the past six months * Clinically significant Chronic Obstructive Pulmonary Disease (COPD) or other pulmonary condition that is not controlled by medication or requires oxygen frequently or continuously * A history of pulmonary emboli * Known hypersensitivity to perflutren, DEFINITY® or other echo contrast agent * Inability to remain supine for 60 minutes * Oxygen saturation \< 95% on room air * History of allergic re…