This Study Include Asthma Chronic Obstructive Pulmonary Disease (COPD) Overlap Patients.Patients Were Vitamin D Deficient.Age Range 40-70 Years, Smokers.Patients Were Advised to Take Either Placebo or Vitamin D3.Lung Functions and Exercise Tolerance Were Assessed at Baseline and at 26th Weeks.

Inclusion Criteria: * Pulmonologist diagnosed patient of ACO * Vitamin D3 deficient : Serum 25(OH)D \<30 ng/ml * Age: 40-70 years * Sex: Male * Socioeconomic status: middle class * Smoker * Anthropometric status: BMI=18.6-24.9 kg mid upper arm circumference\>25.1 cm waist-hip ratio\<0.89 * Serum parathormone: 10-65 pg/ml * Serum Ca2+: 8.5-10.5 mg/dl * Serum PO43: 2.3-4.7 mg/dl * Serum alkaline phosphatase: 30-120 U/L * SGPT: \<50 U/L * Serum creatinine: 0.7-1.3 mg/dl * Fasting Blood Sugar (FBS): 3.5-6.1 mmol/L * Serum HbA1c: 4.5-6.3 % * Serum cholesterol: \<200 mg/dl * Serum HDL: \>40 mg/dl, * Serum LDL: \<130 mg/dl * Serum TG: \<150 mg/dl Exclusion Criteria: * With history of: * any other pulmonary diseases, as, chronic obstructive pulmonary disease bronchial asthma respiratory tract infection bronchiectasis pleural effusion tuberculosis interstitial lung disease pneumonectomy or pulmonary lobectomy * any cardiac disease, like - unstable angina pectoris congestive heart failure myocardial infarction cardiac arrhythmia * systemic hypertension * any liver disease * any malignancy * use of any drugs known to affect vitamin D metabolism within 1 month prior to study, as, antiepileptics (Phenytoin, Carbamazepine) antibiotics (Clotrimazole, Rifampicin) antihypertensives (Nifedipine, Spironolactone) antiretroviral drugs (Ritonavir, Saquinavir) endocrine drugs (Cyproterone acetate) glucocorticoids bisphosphonate calcium supplement * With biochemical evidence of d…