CompletedNot Applicable

Inflammation and Organ Impact During Hepatic Surgery

Sweden18 participantsStarted 2018-11-10

Plain-language summary

Monitoring of inflammatory substances (such as interleukins, CRP, albumine), and markers of organ dysfunction (such as creatinine, proenkephaline, amylase, troponine, IFABP and lactate) during elective liver resection. The study also includes monitoring of hemodynamic parameters, blood loss and postoperative complications. Results are to be used för power calculation for future trials.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: ASA I-III Patient has given informed consent to participate in study. Exclusion Criteria: preoperative kidney failure (E-GFR \>30), current infection treatment with corticosteroids coagulopathy surgical or anatomical conditions that makes patient unsuitable for participation (for example reoperation, need of vascular bypass, single tumor)

What they're measuring

Ischemic Intestinal Damage

Timeframe: from day of surgery until 24-48 hours postoperatively

Kidney injury

Timeframe: from day of surgery and approximately 1 week onwards

Intestinal Bacterial Transloction

Timeframe: from day of surgery until 24-48 hours postoperatively

Kidney injury

Timeframe: from day of surgery until 24-48 hours postoperatively

Kidney injury

Timeframe: from day of surgery until 24-48 hours postoperatively

Trial details

NCT IDNCT03878615

SponsorSahlgrenska University Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-04-02

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