Understanding Cognition, Oxytocin & Pain in Elders
United States83 participantsStarted 2019-08-06
Plain-language summary
Osteoarthritis (OA) represents a significant cause of disability worldwide and the knee is the most commonly affected joint. Oxytocin (OT) is a mediator of endogenous analgesia in animal and human studies. This proposal will test the efficacy and safety of self-administered intranasal OT over 4-weeks in older individuals relative to placebo (P) evaluating its effects on pain and function in aging and testing potential underlying neurobiological mechanisms.
Who can participate
Age range45 Years – 100 Years
SexALL
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Inclusion Criteria:
* knee osteoarthritis/or back pain of at least six months duration, experience pain on more days than not, with moderate pain at baseline (i.e., \> 3/6 in the Visual Descriptor Scale), and who have elevated levels of plasma Imterleukin-6 (\>2.5 pg/ml) will be considered for participation.
Exclusion Criteria:
* Hypersensitivity to OT or vasopressin,
* history of hyponatremia, syndrome of inappropriate antidiuretic hormone secretion, or psychogenic polydipsia,
* on vasoconstrictors such as desmopressin, pseudoephedrine, or antidiuretic medication,
* low sodium and high osmolality levels,
* excessive smoking,
* excessive drinking,
* muscle pain as a result of systemic disease,
* significant nasal pathology,
* previous or concurrent use of narcotics delivered intranasally (e.g., cocaine),
* gastroparesis.
* individuals with heart problems (e.g., cardiomyopathy, history of myocardial infarction, arrhythmias, prolonged QT interval)
* Participants will also be excluded if they have concurrent medical or arthritic conditions that could confound symptomatic knee osteoarthritis-related outcomes or coexisting disease that could preclude successful completion of the protocol including:
* systemic rheumatic condition (e.g. rheumatoid arthritis, systemic lupus erythematosus, fibromyalgia);
* a history of clinically significant surgery to the index knee;
* uncontrolled hypertension (\>150/95);
* poorly controlled diabetes (HbA1c\>7%);
* neurological disease (e.g., Par…