CompletedNot Applicable

The Four Methods of Ovarian Stimulation in Patients With Polycystic Ovarian Syndrome

Iran120 participantsStarted 2016-11-12

Plain-language summary

This study is a randomized controlled clinical trial to compare the pregnancy outcomes of mild and minimal stimulation in infertile women with polycystic ovarian syndrome. The study population consisted of all infertile women with polycystic ovary syndrome based on Rotterdam criteria who have not succeed to achieve fertility despite multiple treatments such as drug therapy, laparoscopic surgery, and the frequent failure of induction therapy using gonadotropins and are now candidate for in vitro fertilization (IVF) or intra cytoplasmic sperm injection (ICSI) in Reproductive Biomedicine Research Center, Royan institute, Tehran Iran.

Who can participate

Age range20 Years – 38 Years

SexFEMALE

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Inclusion criteria

✓. Infertile women with polycystic ovary syndrome based on Rotterdam criterion
✓. 20\<Age\<38
✓. BMI\<30
✓. Non recurrent miscarriage
✓. Non endocrine, hematologic and autoimmune disorders
✓. Non chromosomal and genetic abnormalities
✓. Non uterine anomalies, surgical history, endometriosis, adenomyosis, hydrosalpinx, uterine fibroids
✓. Non azoospermia

What they're measuring

Fertilization rate

Timeframe: 16-18 hours after start of IVF or ICSI, which occurs on day of oocyte pick-up (34-36 hours after hCG administration [approximately Stimulation Day 10]).

Implantation rate

Timeframe: 4 weeks after embryo transfer

Clinical pregnancy rate

Timeframe: 4 weeks after embryo transfer

Trial details

NCT IDNCT03876145

SponsorRoyan Institute

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2019-05-05

View on ClinicalTrials.gov More Polycystic Ovary Syndrome trials