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Ultrasound-assessed Internal Jugular Vein Distensibility in Advanced Chronic Heart Failure (US-IJVD in CHF)

Italy200 participantsStarted 2017-10-18

Plain-language summary

Prospective validation of the ultrasound-assessed internal jugular vein distensibility (JVD) ratio to identify patients with systolic chronic heart failure and right atrial pressure (RAP) of 7 or less mmHg measured by the right heart catheterization. In a calibration cohort, a threshold ratio will be identified, above which the RAP is normal with the highest accuracy. This diagnostic tool with a defined threshold of the JVD ratio will be assessed in a second prospective validation cohort.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * All patients with systolic chronic heart failure defined by a left ventricular ejection fraction (LVEF) \<50% on echocardiogram that, undergo elective RHC in the heart transplant/left ventricular assist device work-up. * In case of occlusion of the left internal jugular vein (IJV), the RHC is performed from to contralateral IJV, and US-assessed JVD ratio will be measured on the right IJV. Exclusion Criteria: * Patients supported by a left ventricular assist device. * Patients with acute heart failure that undergo RHC as an urgent procedure in hemodynamically unstable patients. * Patients unable/unwilling to sign a written informed consent. * Patients in which an RHC is not feasible from an internal jugular vein.

What they're measuring

Identification of patients with normal RAP (=<7 mmHg) with US-IJVD based on the JVD ratio obtained from the calibration cohort.

Timeframe: From July 2017 to June 2019

Trial details

NCT IDNCT03874312

SponsorNiguarda Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-02-27

View on ClinicalTrials.gov More Systolic Chronic Heart Failure trials