Sonodynamic Therapy in the Treatment of Carotid Atherosclerosis

Inclusion Criteria: * Age 18- 80 years * Carotid artery with 30%\~70% stenosis by ultrasound and plaque thickness\>2.5mm * Patients without transient ischemic attack, minor stroke or amaurosis fugax within 6 months * Patients' LDL-c level below 100 mg/dL(2.6mmol/L), well-controlled blood pressure(systolic BP\<140 and diastolic BP\<90 under resting conditions) and diabetes(HbA1c\<7%) * Written informed consent Exclusion Criteria: * Non-atherosclerotic carotid artery stenosis * Contraindication to MRI( uses pacemaker, has metallic implants, claustrophobia) * Acute MI, acute coronary syndrome or stroke within 4 weeks prior to visit * Severe cerebral artery stenosis, atrial fibrillation or MRI detected thrombosis that would cause stroke * Previous significant adverse reaction to a statin * Systemic disorders such as hepatic, renal, hematologic, and malignant disease * Medical history that might limit the individual's ability to take trial treatments for the duration of the study * Allergic to DVDMS or sonovue * Diagnosis of porphyria * Pregnant women and nursing mothers * History of bilateral carotid endarterectomy or has immediate plans for carotid endarterectomy * Patient who is attending other clinical trial