Magnetic Resonance Imaging for Detection of Peritoneal Mesothelioma (NCT03867578) | Clinical Trial Compass
CompletedNot Applicable
Magnetic Resonance Imaging for Detection of Peritoneal Mesothelioma
United States26 participantsStarted 2018-10-10
Plain-language summary
For cancers, such as mesothelioma, that spread to the lining of the stomach, detecting the cancer is very difficult with CT or MRI scans. Researchers at the University of Chicago want to find out if the new experimental MRI and ultrasound imaging techniques do a better job of detecting these cancers. Researchers will use new MRI and ultrasound techniques to see if it can find evidence of cancer that has spread to the lining of the abdomen, and right now these new techniques are only used for research.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. 18 years old or older
✓. Biopsy-proven MPM
✓. Surgery for PM planned at UCM within 60 days
✓. Able to tolerate CT, MRI, US scans, and surgery
✓. Able to provide written informed consent
✓. For women of child bearing age, ability and willingness to use appropriate contraceptive methods before imaging and for a period of 365 days thereafter.
Exclusion criteria
✕. Pregnancy / Breastfeeding
✕. Allergy or intolerance to iodinated or gadolinum contrast dyes
✕. Contraindications to CT or MRI imaging including chronic kidney disease with GFR \<60mL/min/1.73m2
✕. Bioimplants unsuitable for MRI imaging (activated by mechanical, electronic, radiofrequency, or magnetic means), such as cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps
✕. Permanent tattoos or eyeliner with magnetic dyes
✕. Subjects with shrapnel or metal fragments lodged in the body
✕. Anxiety, claustrophobia, or any medical condition that would preclude lying still in an MRI scanner for 1-1.5 hours
What they're measuring
1
Higher Sensitivity for detection using New High Resolution Contrast Enhanced MRI Imaging Sequences compared to standard MRI
Timeframe: 60 Days
2
Higher sensitivity for detection of peritoneal metastatic disease using Ultrasound Elastography compared to standard MRI