Pyruvate Kinase Deficiency Epidemiological Study (PIECE)

INCLUSION CRITERIA: * Informed consent is obtained from the participant or legal representative * The participant is equal or older than 5 years or equal or younger than 30 years old * The participant exhibits the following symptoms of no obvious etiology: * chronic anaemia and/or * splenomegaly and/or * jaundice and/or * cholelithiasis and/or * cholecystitis and/or * hyperbilirubinemia and/or * history of prolonged neonatal jaundice * The participant is clinically diagnosed with PK deficiency EXCLUSION CRITERIA: * Inability to provide informed consent * The participant does not suffer from chronic anaemia and splenomegaly and jaundice and cholelithiasis and cholecystitis and hyperbilirubinemia and history of prolonged neonatal jaundice * The etiology of chronic anaemia or splenomegaly or jaundice or cholelithiasis or cholecystitis or kernicterus is clearly determined and is not due to PK deficiency * The participant is younger than 5 years or older than 30 years old * Previously enrolled in the PIECE Study * Participant in custody