Hepatic Histology and Metabolism Following Total Pancreatectomy and Pancreaticoduodenectomy

Inclusion Criteria: * Subject scheduled for total pancreatectomy or pancreaticoduodenectomy * Informed consent signed prior to any study-related procedure Exclusion Criteria: * Known liver disease before total pancreatectomy or pancreaticoduodenectomy (excluding NAFLD) * Severe co-morbid disease (besides from the indication for the pancreas surgery) * Pregnancy * Any condition that the investigator feels would interfere with the safety of the trial participation or the safety of the subject * Metastatic disease Percutaneous liver biopsy exclusion criteria (to be evaluated before last visit) * MR spectroscopy demonstrating lipid content \<2% * Haemoglobin \<6 mmol/L * INR \>1.5 * Trombocytes \<40 × 109/L * Skin infection in area where biopsy will be sampled