Gastric Emptying - Implications for the Pathogenesis of Type 2 Diabetes (NCT03864562) | Clinical Trial Compass
CompletedNot Applicable
Gastric Emptying - Implications for the Pathogenesis of Type 2 Diabetes
United Kingdom56 participantsStarted 2019-03-01
Plain-language summary
People of black African and Caribbean descent have a greater risk of developing type 2 diabetes than white Europeans. The aim of this study is to increase our knowledge of how the condition may arise, and what underlies this increased risk. Following a successful screening visit to confirm eligibility for the study, we will be investigating how quickly a glucose drink empties out of the stomach in 30 white Europeans and 30 people of black African or Caribbean descent. In addition, we will study the impact that gastric emptying rate has on blood glucose and satiety hormones released normally by the gut in response to eating. Blood and breath samples will be collected before and during an oral glucose tolerance test.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* White European or black African / Caribbean heritage
* BMI \>18 kg/m2
* Ability to give written informed consent
* English speaking
Exclusion Criteria:
* Any significant medical condition
* Uncontrolled hypertension
* Alcohol consumption \>14 units / week
* Random blood Glucose concentration above 7.8mmol/l
* Hemoglobin A1c (HbA1c) \>47mmol/mol (\>6.4%)
* Use of regular medication, (oral contraceptive pill or antihypertensive medication are acceptable if use has been for \>6 months)
* History of Irritable Bowel Syndrome, food intolerances or any gastrointestinal disorders
* Previous bariatric surgery, or gastrointestinal surgery which may affect normal function (e.g. bowel resection)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.