CompletedNot Applicable

The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Living Donor Liver Transplantation Under Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial

South Korea120 participantsStarted 2019-02-17

Plain-language summary

Prolonged corrected QT interval (QTc) has been observed in about half of patients with liver cirrhosis. Marked prolongation of QTc (ie, 500 msec) has been considered to be a risk factor for fatal ventricular arrhythmia, such as torsade de pointes,7,8 which has been reported in liver transplantation (LT) surgery. In a previous study, prolonged QTc interval ( 500 msec) was frequently observed throughout the procedure of LT, even among patients with baseline QTc 440 msec. Therefore, it is important to optimize electrolyte balance and hemodynamic status to reduce greater risk of perioperative arrhythmias. The investigators hypothesized that the change of QTc interval might be differ according to method of general anesthesia (inhalation agent vs. intravenous agent).

Who can participate

Age range20 Years

SexALL

See this in plain English?

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Inclusion Criteria: * patients with liver cirrhosis who will undergo planned liver transplantation Exclusion Criteria: * 1\. emergent liver transplantation * 2\. unstable angina * 3\. recent MI(Myocardial Infarction) * 4\. uncontrolled hypertension (diastolic BP \> 110mmHg) * 5\. implantable cardiac defibrillator * 6\. severe obesity (BMI\>30kg/m2) * 7\. allergy to propofol

What they're measuring

QTc interval

Timeframe: 3 minutes after liver reperfusion

Trial details

NCT IDNCT03864276

SponsorYonsei University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-12-31

View on ClinicalTrials.gov More Liver Cirrhosis(Who Will Undergo Planed Liver Transplantation) trials