CompletedPhase 4

Hemodynamics During Induction of General Anesthesia After Prophylactic Ephedrine, Phenylephrine or Norepinephrine.

Norway128 participantsStarted 2022-03-15

Plain-language summary

In this trial the investigators want to examine if there is any difference in hemodynamic stability when giving equipotent prophylactic injections of ephedrine 0,1 mg/kg, phenylephrine 1 microg/kg, norepinephrine 0,1 microg/kg or sodium chloride (NaCl) 9 mg/ml during induction of general anesthesia with propofol and remifentanil.

Who can participate

Age range18 Years – 50 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy women * Age 18-50 years * Gynecological procedures * General anesthesia Exclusion Criteria: * Pre-existing hypertension * Diabetes for several years * Ischemic heart disease * Cerebrovascular disease * Heart valve disease * Verified cardiac arrhythmia * Anaemia * Kidney or hepatic disease * Hypersensitivity for soya, eggs or peanuts * Pregnancy * Poor health state * Illicit substance use * BMI \<20 or \>35 kg/m2 * SBP \>150 mmHg * HR \>100 beats/min

What they're measuring

Systolic Blood Pressure (SBP)

Timeframe: First 7,5 minutes from start of induction

Heart Rate (HR)

Timeframe: First 7,5 minutes from start of induction

Trial details

NCT IDNCT03864094

SponsorHelse Fonna

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-14

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