UnknownNot Applicable

PRP vs PRP+IVC for Severe nPDR

China40 participantsStarted 2019-01-18

Plain-language summary

The randomized clinical trial aims to compare the therapeutic effects between panretinal photocoagulation(PRP) and PRP combined with intravitreal conbercept (IVC) injection in severe nPDR with/without diabetic macular edema patients.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. severe non-PDR in either eyes with/without diabetic macular edema;
✓. ETDRS letters-measured best-corrected visual acuity (BCVA) ranging from 20/40 to 20/320 Snellen equivalent;
✓. no previous treatment (of any type) in either eye.

Exclusion criteria

✕. history of prior laser treatment or vitrectomy in the study eye;
✕. history of thromboembolic event - including myocardial infarction or cerebral vascular accident;
✕. major surgery within the prior 6 months or planned within the next 28 days;
✕. history of glaucoma or ocular hypertension;
✕. loss of vision as a result of other causes;
✕. history of systemic corticosteroid therapy within the last 3 months;
✕. severe systemic disease other than diabetes mellitus;
✕. known coagulation abnormalities or current use of anticoagulative medication other than aspirin

What they're measuring

Change in best-corrected visual acuity (BCVA)

Timeframe: from baseline to month 12

Trial details

NCT IDNCT03863535

SponsorRuijin Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-01-01

Contact for this trial

Xi Shen, MD

+86-021-64370045 carl_shen2005@126.com

View on ClinicalTrials.gov More Severe Nonproliferative Diabetic Retinopathy trials