UnknownNot Applicable

PRP vs PRP+IVC for Severe nPDR

China40 participantsStarted 2019-01-18

Plain-language summary

The randomized clinical trial aims to compare the therapeutic effects between panretinal photocoagulation(PRP) and PRP combined with intravitreal conbercept (IVC) injection in severe nPDR with/without diabetic macular edema patients.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. severe non-PDR in either eyes with/without diabetic macular edema;
. ETDRS letters-measured best-corrected visual acuity (BCVA) ranging from 20/40 to 20/320 Snellen equivalent;
. no previous treatment (of any type) in either eye.

Exclusion criteria

. history of prior laser treatment or vitrectomy in the study eye;
. history of thromboembolic event - including myocardial infarction or cerebral vascular accident;
. major surgery within the prior 6 months or planned within the next 28 days;
. history of glaucoma or ocular hypertension;
. loss of vision as a result of other causes;
. history of systemic corticosteroid therapy within the last 3 months;
. severe systemic disease other than diabetes mellitus;
. known coagulation abnormalities or current use of anticoagulative medication other than aspirin

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in best-corrected visual acuity (BCVA)

Timeframe: from baseline to month 12

Trial details

NCT IDNCT03863535

SponsorRuijin Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-01-01

Contact for this trial

Xi Shen, MD

+86-021-64370045 carl_shen2005@126.com

View on ClinicalTrials.gov More Severe Nonproliferative Diabetic Retinopathy trials