CompletedNot Applicable

Evaluation of Effect of Bone Marrow Aspirate Concentrate on Distracted Mandibular Bone Properties

12 participantsStarted 2015-12-30

Plain-language summary

Maxillofacial Distraction Osteogenesis (DO) has a lot of draw backs; mostly related to long distraction and consolidation time. Rapid rate DO was proposed to decrease the distraction time to avoid consequences of long procedure. The idea of the current study is to provide mesenchymal stem cells (MSCs) in form of Bone Marrow Aspirate Concentrate (BMAC) during rapid distraction to fasten and shorten consolidation. Methods: This trial was conducted on patients requiring mandibular DO. Patients were divided in two groups; control group in which distraction took place at a rate of 1.5 mm /day without any enhancement and study group in which distraction took place at rate of 1.5 mm /day and the distracted bone was enhanced by BMAC

Who can participate

Age range6 Years – 25 Years

SexALL

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Inclusion criteria

✓. Patients free from any disease affecting bone formation of both sexes was included in the study.
✓. Patients younger than 25 years old.
✓. Patients included in the study were post traumatic patients, hemifacial microsomia, Treacher Collins and post ankylotic mandibular deformity.
✓. Distraction range was between 15-20 mm.

Exclusion criteria

✕. The presence of uncontrolled systemic disease.
✕. Previous radiotherapy on head and neck region.
✕. Chemotherapy within the past 12-month period.
✕. An active infection at the distraction site.

What they're measuring

Assessment of effect of BMAC on rapidly distracted bone quality

Timeframe: 6 months

Trial details

NCT IDNCT03861650

SponsorYasser Mohamed Nabil Ahmed Khirat El Hadidi

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-12-30

View on ClinicalTrials.gov More Hemifacial Microsomia trials