RecruitingNot Applicable

Visual Remapping to Aid Reading With Field Loss

United States108 participantsStarted 2022-02-01

Plain-language summary

Reading performance in patients with Central Vision Loss and age matched controls with artificial scotomas will be measured with and without different kinds of remapping of missing text to different parts of the visual field.

Who can participate

Age range

16 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. 16 years or older
. Central vision loss of at least 5 deg diameter, including the fovea, from bilateral central scotomas
. Stable fixation (+/- 1 deg) using their PRL.
. No cognitive impairment as indicated by a Mini-Mental State Examination (MMSE).
. Satisfactory calibration achievable using eye tracker

Exclusion criteria

. Central vision loss of less than 5 deg diameter; scotomas that do not cover the fovea; unilateral scotomas
. Poor fixation (worse than+/- 1 deg) using their PRL.
. Cognitive impairment as indicated by a Mini-Mental State Examination (MMSE).
. Satisfactory calibration not achievable using eye tracker

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Reading Speed for Individual Words

Timeframe: Measured during third visit- each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day

Reading Speed for Sentences

Timeframe: Measured during fourth visit- each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day

Reading Speed for Natural Text Samples

Timeframe: Measured during fifth visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day

Reading error rate for Individual Words

Timeframe: Measured during third visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day

Reading error rate for Sentences

Timeframe: Measured during fourth visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day

Reading error rate for Natural Text Samples

Timeframe: Measured during fifth visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day

Trial details

NCT IDNCT03848663

SponsorUniversity of Minnesota

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-07-01

Contact for this trial

Stephen Engel, Ph.D.

612-625-5571 engel@umn.edu

View on ClinicalTrials.gov More Age-related Macular Degeneration trials

Who can participate

Age range

16 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. 16 years or older
. Central vision loss of at least 5 deg diameter, including the fovea, from bilateral central scotomas
. Stable fixation (+/- 1 deg) using their PRL.
. No cognitive impairment as indicated by a Mini-Mental State Examination (MMSE).
. Satisfactory calibration achievable using eye tracker

Exclusion criteria

. Central vision loss of less than 5 deg diameter; scotomas that do not cover the fovea; unilateral scotomas
. Poor fixation (worse than+/- 1 deg) using their PRL.
. Cognitive impairment as indicated by a Mini-Mental State Examination (MMSE).
. Satisfactory calibration not achievable using eye tracker

What they're measuring

Reading Speed for Individual Words

Timeframe: Measured during third visit- each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day

Reading Speed for Sentences

Timeframe: Measured during fourth visit- each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day

Reading Speed for Natural Text Samples

Timeframe: Measured during fifth visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day

Reading error rate for Individual Words

Timeframe: Measured during third visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day

Reading error rate for Sentences

Timeframe: Measured during fourth visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day

Reading error rate for Natural Text Samples

Timeframe: Measured during fifth visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day