Melatonin is a hormone that regulates the circadian cycle in addition to having an antioxidant effect. Patients with prediabetes state, has a deregulation of glucose metabolism and an overproduction of reactive oxygen species caused by levels of hyperglycemia that generate DNA modification in pancreatic beta cells, which leads to apoptosis and a deficient production of insulin. The administration of metformin and melatonin could be a possibility to treat and reverse the prediabetic state decreasing the glycemic levels and reactive oxygen species production.
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Fasting plasma glucose (FPG)
Timeframe: Baseline to week 12
Blood Glucose level after an Oral Glucose tolerance Test
Timeframe: Baseline to week 12
A1c Hemoglobin Fraction (HbA1C)
Timeframe: Baseline to week 12
Micronuclei frequency
Timeframe: Baseline to week 12
Nuclear anomalies frequency
Timeframe: Baseline to week 12