Defining the Genetics, Biomarkers and Outcomes for Dilated Cardiomyopathy

PART 1 Inclusion Criteria: * Male or female participants of any age * Capacity to provide informed consent * Patients with a confirmed diagnosis of DCM * Affected family members of patients meeting diagnostic criteria for DCM Exclusion Criteria: * DCM attributed to chemotoxicity (from chemotherapeutic agents, drugs of abuse) * DCM attributed to systemic inflammatory myopathies (eg sarcoid, systemic lupus erythematosus) * Patients who lack capacity to consent for themselves * Patients with a confirmed history of coronary artery disease, assessed using standard UK clinical practice guidelines, defined as one or more of the following:- * \>50% narrowing, any major epicardial coronary artery on invasive or computed tomography coronary angiography * CMR suggestive of previous myocardial infarction of ≥2 segments of ≥50% infarction of the LV wall * Previous percutaneous coronary intervention or coronary bypass surgery * History of primary valvular heart disease or congenital heart disease * Severe, untreated or untreatable hypertension (systolic blood pressures routinely \>180 mm Hg and/or diastolic blood pressures \>120 mm Hg) PART 2 Inclusion Criteria: * Males or females of any age * Capacity to provide informed consent * Patients with hypokinetic non-dilated cardiomyopathy, or * Family members of DCM patients with possible or probable DCM or * Patients with a confirmed diagnosis of heritable cardiovascular disease or * Family members of patients with heritable card…