Characterizing Clinical and Pharmacological Neuroimaging Biomarkers

Inclusion Criteria: * For BOTH Non-Healthy Controls and Healthy Controls: * Right-handed as determined by the Edinburgh handedness questionnaire (Oldfield, 1971). * Premorbid IQ\>70 determined by WAIS similarities and matrix reasoning subtests; Any history indicating learning disability, mental retardation, or attention deficit disorder will exclude the subject from participation. * Must speak or read English at least 8th grade level or higher and to complete study evaluations. * Must have intact vision or vision that can be corrected by glasses or contact lenses (corrected 20 20/20). * Must be able to tolerate enclosed spaces \*\* only if participating in MRI portion. * Female subjects must be postmenopausal for a least 1 year, surgically sterile, or using a reliable method of contraception at screening. Reliable methods of contraception include double-barrier methods (e.g. condom and diaphragm, condom and foam, condom and sponge), intrauterine devices, or hormonal birth control methods. Women with positive serum pregnancy results at screening or self-reporting of pregnancy will be excluded from the study. \*\* only if participating in MRI portion. * Must be free of metallic foreign objects in body, such as aneurysm clips or pacemakers, or a questionable history of metallic fragments \*\* only if participating in MRI portion. * For Non-Healthy Controls Participants: * Adult patients from the community meeting diagnostic criteria for schizophrenia, schizoaffective disorder, …