UnknownNot Applicable

Temporal Relations and Exercise Interventions of Various Gait and Cognitive Domains in Older Adults

Taiwan189 participantsStarted 2019-02-15

Plain-language summary

The effectiveness of conventional exercise, tai chi chuan and health education/usual physical activity over a 6-month intervention period in improving primary outcomes and secondary outcomes in older mild cognitive impairment adults will be compared. Third, whether changes in serum levels of the brain-derived neurotrophic factor (BDNF), insulin-like growth factor (IGF)-1, and vascular endothelial growth factor (VEGF) and expression of the apolipoprotein E (APOE) ε4 allele parallel changes in gait characteristics and cognitive functions after the intervention will be examined.

Who can participate

Age range65 Years – 100 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * At least 65 years old * Had an emergency department visit due to a fall at least 3 months prior to the baseline assessment (assuming a full recovery time from a fall to be 3 months) * Can ambulate independently * Has mild cognitive impairment Exclusion Criteria: * Do not live in a community setting * Cannot ambulate independently and communicate with researchers * Have a major unstable cardiopulmonary disease (e.g., ischemic chest pain, shortness of breath, recurrent syncopal episodes, orthopnea, paroxysmal nocturnal dyspnea, palpitations, or tachycardia) * Have a contraindication to physical exercise (e.g., severe osteoarthritis or severe pulmonary hypertension)

What they're measuring

Gait characteristics

Timeframe: 12 months

Global cognition

Timeframe: 12 months

Serum levels of BDNF

Timeframe: 12 months

Serum levels of IGF-1

Timeframe: 12 months

Serum levels of VEGF

Timeframe: 12 months

Trial details

NCT IDNCT03839563

SponsorTaipei Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-31

Contact for this trial

Mau-Roung Lin, Professor

886-2-27361661 mrlin@tmu.edu.tw

View on ClinicalTrials.gov More Fallers trials

Plain-language summary

Who can participate

Age range65 Years – 100 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.